The phrase “I don’t know him from Adam” suggests that if the person were standing next to the person in Western tradition thought to be earliest human being, the two would be indistinguishable. The phrase “I don’t know her from Adam” can be used to refer to a woman who is similarly unrecognizable, but it’s less common. Another variation: “I wouldn’t know him from Adam’s off ox.” This is part of a complete episode.
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My dad uses the expression “doesn’t know from Adam”.